Reviewed October 5, 2026 · Selected publications, not a systematic review
Crocodile peptide research includes laboratory antimicrobial and cell-protection findings. Great white shark research includes genomic adaptations associated with wound healing and DNA maintenance.
Study highlights
Each entry identifies what was tested and what remains unproven.
Cell experiment
Crocodile peptides studied in stressed skin cells
Taemaitree and colleagues studied Siamese crocodile (Crocodylus siamensis) white blood cell extracts and derived peptides in cultured HaCaT skin cells. NV10 and RI10 reduced oxidative-stress markers and cell death under the tested conditions.
Limit: Human-derived cells in a dish are not a clinical trial in people. This does not demonstrate skin, anti-aging or oral-supplement benefits.
A saltwater crocodile defensin targets fungal membranes
Williams and colleagues characterized CpoBD13 from the saltwater crocodile (Crocodylus porosus). Laboratory work showed pH-dependent antifungal activity through phospholipid binding and membrane disruption.
Limit: An isolated host-defense peptide is not equivalent to a commercial protein hydrolysate. The study does not establish treatment of fungal infections or benefits from consuming crocodile sachets.
Leucrocin peptides show antibacterial activity in laboratory tests
Pata and colleagues isolated four short Leucrocin peptides from Siamese crocodile white blood cells. They reported activity against selected bacteria under laboratory conditions.
Limit: This does not establish prevention or treatment of infections in people, an effective oral dose, or the presence of those peptides in our formula.
Great white shark DNA offers clues about repair pathways
Marra and colleagues sequenced the great white shark (Carcharodon carcharias) genome and found evolutionary adaptations in genes associated with genome stability and wound-healing pathways.
Limit: This is a genome study, not a peptide feeding trial. It does not show that eating shark material repairs human DNA, heals wounds or prevents cancer.
Shark cartilage clinical results provide an important counterpoint
A randomized phase III trial involving 379 eligible patients found that adding the shark cartilage extract AE-941 to chemoradiotherapy did not improve overall survival in unresectable stage III non-small cell lung cancer.
Limit: AE-941 is a different product; this is not a trial of our formula or proof of a great white shark peptide benefit. Laboratory promise must be evaluated against human outcomes.
Our short summaries link to the original reports. Publication dates are shown so historical coverage is not mistaken for a new discovery. Several outlets cover the same study; repeated coverage is not independent scientific confirmation.
Phys.org March 2, 2023 · La Trobe University release
How crocodile defensins respond to their surroundings
Coverage of the CpoBD13 mechanism and its potential as a starting point for future drug development. The underlying research was laboratory work.
Interest in crocodile compounds for medical research
Researchers and industry experts discuss crocodilian blood compounds and possible antibiotic development. Reported aspirations and commercial interest do not establish clinical effectiveness.
Reporting on great white shark genomics and possible biomedical research directions. A researcher explicitly rejects the idea that consuming shark products transfers those characteristics to people.
Publisher names identify sources only. No outlet has been verified as reviewing, endorsing or featuring this product. Summaries are original wording; articles and publisher logos are not reproduced.
What the evidence means for our sachets
Species and materials matter. Siamese crocodile, saltwater crocodile, alligator, shark cartilage and great white shark DNA are distinct research subjects. Results from one are not automatically applicable to another.
The product connection is unverified. The studies above do not establish the peptide identities, amounts, digestive stability, absorption, safety or clinical effects of the finished formula. A disease-treatment, infection-prevention, DNA-repair or anti-aging benefit is not supported for our sachets by these sources.
Claims require relevant evidence. FDA describes requirements for substantiated supplement structure/function claims. FTC evaluates both explicit and implied advertising claims and explains that disclaimers do not fix misleading health claims. Historical private legal opinions and links to research do not provide FDA approval or immunity from lawsuits.